Abstract

Background/Aim: Ovarian cancer (OC) is the 5th most common cancer deaths cause in females, and has also the worst prognosis. Periodontal Disease (PD) has been associated with several diseases, such as cardiovascular diseases (CVD), diabetes mellitus (DM), and several types of cancer, such as esophageal, gastric, lung, colorectal, oral, pancreatic, head and neck, and ovarian cancers. The study was conducted to assess the possible relationsgip between PD indices, and missing teeth number and the risk of developing OC in a sample of Greek adults females. Materials and Methods: The study was conducted between March 2021 and March 2024 and consisted of 348 females,ages 50 to 83 years. 116 were suffered from epithelial OC and 232 were healthy individuals. The examined PD indices, concerned depth of Periodontal Pockets (PPD), Gingival inflammation index (GI), Attachment Loss (CAL), Bleeding on Probing (BOP), and missing teeth number by a self-administered questionnaire and a clinical examination of oral and dental status. Data analysis was carried out using univariate and logistic regression models. Results: Statistical analysis showed that low socio-economic status (p< 0.001), presence of a OC family history (p<0,001), increased body mass index (BMI) (p= 0.01), incessant ovulation (p<0.001), early age of menarche (p=0.001), GI (p=0.003), and BOP (p=0.06) were significantly associated with the risk of OC developing. Conclusion: Females with a lower socio-economic status, a OC family history, increased body mass index (BMI), incessant ovulation, early age of menarche, and presence of BOP were significantly associated with the risk of OC developing