Abstract

Diabetes is a metabolic disorder characterized by partial or complete insulin deficiency due to endocrine dysfunction of the pancreas or systemic hyperglycemia secondary to insulin resistance in peripheral tissues. In addition to common symptoms such as polyuria, polydipsia, fatigue, dry mouth, weight loss, blurred vision, itching, persistent and recurrent fungal infections. Diabetes can also manifest itself with less common symptoms such as infections. Since diabetes is a chronic disease, it brings with it various complications. These complications are divided into two basic groups: microvascular and macrovascular. One of the most common microvascular complications is neuropathy. Diabetic foot, which develops as a result of infection and ischemia along with neuropathy, accounts for a significant portion of lower extremity amputations. In the pathophysiology of neuropathy, impaired microcirculation, sorbitol and glycosylated metabolic residues cause myelinated and non-myelinated nerve loss . Motor neuropathy, along with foot deformity, creates a tendency to change the pressure distribution on the sole of the foot and to ulceration. Related to diabetic foot. It is possible to evaluate the problems as Charcot neuroarthropathy, foot ulcers and acute widespread infections. In diabetic foot ulcers, the patient’s quality of life is significantly affected, the patient may also experience difficulties in social life and ulcers may result in amputation. Approximately 40-60% of non-traumatic lower extremity amputations are affected. causes diabetic foot ulcers. Hypericum Perforatum L., popularly known as St. John’s wort, is a plant frequently used in our country and all over the world due to its contributions to wound healing. Its effectiveness on almost all stages of wound healing, its anti-inflammatory, antibacterial and antiviral, immunity-enhancing and wound healing-accelerating effects are also confirmed by studies supported. The major components that contribute to wound healing are hyperforin, a phloroglucinol derivative, and hypericin, a naphthodianthrone. Additionally, hypericin is the component that gives St. John’s wort oil its dark color.The effect of St. John’s wort was examined in our patient who developed a diabetic ulcer.